Mednafen is the best emulator for playing GameBoy Advance and Virtual Boy games on Mac. Its PlayStation emulation is still being worked on, but it already boasts incredible compatibility. Until OpenEmu is ready for prime time, this is THE emulator to use for the 16-bit era and older. More people need to try this emulator!
Mednafen emulates over 15 consoles, impressively well, but is barely mentioned on this site. The News Roundup mentions it on occasion, but only the Nekolauncher frontend. The frontend is worthless without the backend and it's not posted on the author's site.
Another user and I have been posting Mac binaries on the Mednafen Forum for over a year.
Check it out! Download the first zip file and give it a try. No command line knowledge required; just run the app in the download and you'll get a nice graphical interface. Playing a game is as easy as File --> Open.
Enjoy!