For those of you who are unaware, speedrunning site Speed Demos Archive is hosting their third annual Awesome Games Done Quick charity marathon- roughly a week of live streaming 24/7 video game speedruns.  AGDQ1 9CGDQ) raised ~$25k.  AGDQ2 raised over $50k.  This year they're a bit over half way through and well on their way to $100k.  All proceeds go to the Prevent Cancer Foundation.
It's really an awesome event to tune into, as they also have a live-in-room camera stream and do crazy special events like a (now past) Castlevania run with the background music performed live, a 2-players-1-controller Contra run (upcoming) and donation prizes for nearly every game.
Streams, donations and webchat are at
 http://speeddemosarchive.com/
Game list, prizes and schedule are at
 http://speeddemosarchive.com/marathon/schedule/
and the currently raised amounts for each challenge are at
 http://donations.uranium-anchor.com/tracker/choices/ when the site isn't overwhelmed
Oh, and the grand prize drawing for donations of $30+ is a replica OoT Master Sword.  Like, actual to-scale metal custom work.