I've been getting into this a bit more lately, since I like Wine and figure that video-based applications play an important role in its development. As such, I've contributed some info to the AppDB on the official site. Some examples:
Test data for 1964
Maintainer for Project64 1.6
Maintainer for pSX 1.13
Maintainer for Snes9x 1.52
As you might notice, there's a big lack of Mac OS X contributors, so I thought I'd get involved.
If you read the Snes9x one, you can see that I actually got it working right. I learned how to work around the main issues and found that netplay with Windows users works. It's a great alternative, since the Mac port of this emulator only supports Mac-to-Mac connection. The worst problem with it is that it won't recognize USB controllers, but if you don't mind using the keyboard it's just fine. Alternatively, you can use ZSNES 1.42. Netplay with Windows users works great, and USB controllers are recognized no problem.
And for those who like hi-res texture packs:
For those who may be interested in this stuff, I recommend you download wine-devel from MacPorts, and then winetricks. With winetricks you can install various runtime libraries and other stuff often needed for video-based applications.