In my opinion, I find that playing the original cartridge on the original hardware to be an easier, more relaxing experience. Less of a hassle at any rate. That said, some games (and consoles) are just too hard to come by to justify holding off until you find an original copy, like EarthBound, and some games never received a proper translation, so you've got to use a fan translation, which usually means piracy and emulation.
Now for that most recent poll, there was no option that fits me. Several Macs (six of 'em) and a PC running Linux (Debian, to be precise), so I chose multiple Macs.